The community has always suspected Vex in Borderlands 4 (BL4) to be among the most powerful Vault Hunters. Thanks to discoveries from players like NickTew, an infinite damage build has surfaced — and it’s breaking the game in the best possible way. Using the right gear and talents, Vex can obliterate bosses in seconds, even on Ultimate Vault Hunter Rank 5.
Here’s everything you need to know about how this BL4 Vex Infinite Damage build works, what items you’ll need, and how to set it up.
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Why the Borderlands 4 Vex Infinite Damage Build Works
At the core of this build is the Penetrator Augment for the Throwing Knife Ordinance. This augment ensures that every attack against an impacted enemy counts as a critical hit for 5 seconds.
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Pair that with Bloodletter (x5) from Vex’s Green Talent Tree, and you unlock the synergy:
- Bloodletter makes Gun and Skill Critical Hits apply Bleed, which creates a Kinetic Status Effect Damage over time.
- This Bleed damage is classified as Gun damage, enhanced by Status Effect Application Chance, and can trigger more bleeds.
- With enough Status Effect Application Chance, the effect loops endlessly, leading to practically infinite damage until the enemy dies.
How to Set Up the Vex Infinite Damage Build in BL4
Here’s what you’ll need to pull this off:
- Throwing Knife Ordinance with the Penetrator Augment
- High-damage, single-hit weapons (Shotguns and Sniper Rifles are best)
- 5 points in Bloodletter Talent
- Contamination Specialization (optional, but boosts Status Effect Chance)
- A Repkit with Amp for massive burst potential
Step-by-Step Setup
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Equip your Penetrator Augment Knife.
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Throw it at an enemy to prime the critical damage window.
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Fire a single, heavy-damage shot (preferably a Shotgun or Sniper).
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Watch the infinite bleed loop shred bosses in seconds.
Why This Build Is So Strong
Even though it relies on finding a rare Throwing Knife, the payoff is game-breaking. NickTew demonstrated that with just 15 talent points and a level 32 weapon on a level 50 Vex, he completely destroyed the Vault of Inceptus boss in seconds.
This synergy is so strong it may eventually be patched or nerfed, but even after adjustments, the Bloodletter and Penetrator combo will remain one of the most lethal setups in Borderlands 4.
If you’re lucky enough to find a Penetrator Throwing Knife early, don’t let it go. Pair it with Bloodletter and a solid shotgun or sniper, and you’ll unlock the Borderlands 4 Vex Infinite Damage build — one of the most devastating combos in BL4 right now.
Whether it stays or gets nerfed, this build proves that Vex might just be the strongest Vault Hunter in Borderlands 4.
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